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Effects of Moderate and Intensive Training on the Hypothalamo–pituitary–adrenal Axis in Rats by M. CHENNAOUI; D. GOMEZ MERINO; J. LESAGE; C. DROGOU; C. Y. GUEZENNEC is a Medicine article available to read on EtoBox.

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## ABSTRACT The influence of the two distinct training programmes, moderate (M) and intensive (I), on hypothalamo–pituitary–adrenal (HPA) axis was investigated, in rats. Changes in plasma concentrations of adrenocorticotropin hormone (ACTH) and corticosterone were followed in response to (i) a 60‐min acute running session performed on 2nd, 4th and 6th of the seven training weeks (ii) an acute restraint stress of 40 min applied after the final training programme. After 2nd, 4th and 6th week of the two training programmes, a 60‐min running resulted in an enhanced secretion of ACTH and corticosterone, compared with both the baseline values (i.e. before running) and to the sedentary (S) group. However, on 4th and 6th weeks compared with 2nd week, ACTH and corticosterone remained elevated in intensive group when they are significantly reduced in moderate group. We could suggest that a moderate training resulted in an adapted hormonal response whereas a deadapted process occurred for the intensive programme. The day after the last training session, basal ACTH, corticosterone and corticosteroid‐binding globulin (CBG) capacity were not affected by training. Hypothalamic corticotropin‐relea

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Author

M. CHENNAOUI; D. GOMEZ MERINO; J. LESAGE; C. DROGOU; C. Y. GUEZENNEC

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0001-6772)

Published

2002

Language

EN

Field

Medicine (Life Sciences)