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220. A Meta-Analysis of the Differential Effects of Antidepressants on the Autonomic Nervous System by Dimitri Fiani; Hannah Campbell; Marco Solmi; Jess Fiedorowicz; Chadi Calarge is a Neuroscience article available to read on EtoBox.

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Background: Irritability is a prominent symptom of perinatal depression (PND). Previous research has validated the experimental manipulation of reproductive hormones to mimic the perinatal period in non-pregnant, euthymic women and to distinguish between hormone-sensitive (HS+) and nonhormone-sensitive (HS-) women. To determine how female reproductive hormones regulate neural dysfunction that leads to irritability in PND, we conducted an experimental hormone manipulation and functional magnetic resonance imaging (fMRI) study in HS+ females and controls.Methods: HS+ participants (n1⁄411) and HS-controls (n1⁄412) received a baseline leuprolide acetate injection (Lupron; 3.75mg) to induce stable hypogonadism. Following one month in a hypogonadal state, participants began a two-week hormone "add-back", using micronized estradiol and progesterone tablets (4mg/day and 400mg/day, respectively). fMRI scans were performed at baseline and at the conclusion of hormone addback on a 7T Siemens MR scanner. Scans included the Affective Posner task to induce frustration. During frustration runs, 60% of correct responses were followed by rigged feedback and 40% of correct responses were followed by

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Author

Dimitri Fiani; Hannah Campbell; Marco Solmi; Jess Fiedorowicz; Chadi Calarge

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Neuroscience (Life Sciences)