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CYP3A4 and CYP11A1 variants are risk factors for ischemic stroke: a case control study by Gao, Ning; Tang, Hong; Gao, Ling; Tu, Guolong; Luo, Han; Xia, Ying is a Medicine article available to read on EtoBox.
What is CYP3A4 and CYP11A1 variants are risk factors for ischemic stroke: a case control study about?
## Background This study aimed to investigate the roles of __CYP3A4__ and __CYP11A1__ variants in ischemic stroke (IS) susceptibility among the Han Chinese population. ## Methods Four hundred seventy-seven patients with IS and 493 healthy controls were enrolled. Seven single-nucleotide polymorphisms (SNPs) of __CYP3A4__ and __CYP11A1__ were genotyped by Agena MassARRAY. Odds ratio (OR) and 95% confidence intervals (CI) were calculated by logistic regression adjusted for age and gender. ## Results We found that __CYP3A4__ rs3735451 (OR = 0.81, __p__ = 0.039) and rs4646440 (OR = 0.72, __p__ = 0.021) polymorphisms decreased the risk of IS. __CYP3A4__ rs4646440 (OR = 0.74, __p__ = 0.038) and __CYP11A1__ rs12912592 (OR = 1.58, __p__ = 0.034) polymorphisms were correlated with IS risk in males. __CYP3A4__ rs3735451 (OR = 0.63, __p__ = 0.031) and rs4646440 (OR = 0.57, __p__ = 0.012) possibly weaken the IS susceptibility at age > 61 years. Besides, __CYP3A4__ rs4646437 (OR = 0.59, __p__ = 0.029), __CYP11A1__ rs12912592 (OR = 1.84, __p__ = 0.017) and rs28681535 (OR = 0.66, __p__ = 0.038) were associated with IS risk at age ≤ 61 years. __CYP11A1__ rs28681535 TT genotype was higher high-densi
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- Author
- Gao, Ning; Tang, Hong; Gao, Ling; Tu, Guolong; Luo, Han; Xia, Ying
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-2377)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)