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An interleaved sampling strategy for MR spectroscopy in vivo: Applications on human calf musculature☆ by Jürgen Machannab; Fritz Schick; Stephan Jacob; Otto Lutz; Claus D. Claussen is a Medicine article available to read on EtoBox.

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Assessment of relaxation times, magnetization transfer rates, or apparent diffusion coefficients by volume selective 1 H MR spectroscopy requires data from several single spectra with variable sequence parameters. Unintentional movements during the examination lead to inaccuracies, especially if the spatial distribution of concentrations is inhomogeneous. Improved comparability of the single spectra in a series recorded in vivo were obtained using a modified spectroscopic technique with INTerleaved ACquisiTion of multiple SPECtra (INTACTSPEC). INTACTSPEC series of spectra from the tibialis anterior muscle (m. tib. ant.), soleus muscle (m. soleus), and tibial bone marrow of 20 healthy volunteers were analyzed. Transverse relaxation times T 2 of methylene signals in muscular lipid stores ranged from 77 ms (intramyocellular methylene component in m. tib. ant.) to 88 ms (intramyocellular methylene component in m. soleus) and were similar to those from yellow tibial bone marrow (T 2 ϭ 84 ms). Echo time-dependent signal intensities of choline and creatine deviated markedly from a monoexponential behavior in m. tib. ant., but were nearly exponential in m. soleus. Results from water diffus

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Author

Jürgen Machannab; Fritz Schick; Stephan Jacob; Otto Lutz; Claus D. Claussen

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0730-725X)

Published

2000

Language

EN

Field

Medicine (Health Sciences)