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Membrane Sensors for the Selective Determination of Fluorouracil by Saad S. Hassan; Mohamed M. Amer; Soheir A. Abd El-Fatah; Amira M. El-kosasy is a Chemistry article available to read on EtoBox.

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The construction and electrochemical response characteristics of poly(vinyl chloride) matrix membrane sensors for ̄uorouracil are described. The membranes incorporate ion association complexes of ̄uorouracil anion with bathophenanthro-line±nickel(II) [sensor 1], bathophenanthroline±iron(II) [sensor 2] and phenanthroline±iron(II) [sensor 3] as electroactive materials. These sensors show linear response for ̄uorouracil over the range 1.3±130 mg ml À1 , with anionic slopes of 29.0, 27.9 and 34.3 mV per concentration decade with sensors 1, 2 and 3, respectively. These sensors exhibit fast response time (1.0±1.5 min), low determination limit (110 À5 M), good stability (4±8 weeks) and reasonable selectivity. The sensors were used for direct potentiometry and potentiometric titration of ̄uorouracil in some pharmaceutical preparations. Results with mean accuracy of 98.6AE0.9% of nominal were obtained which compare well with data obtained using the British Pharmacopoeial method. The sensors were also used to follow the stability of the drug in the presence of its degradates, namely formaldehyde, ̄uoroacetate and urea. In the presence of glycine, these products have no effect on the re

Who reads Membrane Sensors for the Selective Determination of Fluorouracil?

Author

Saad S. Hassan; Mohamed M. Amer; Soheir A. Abd El-Fatah; Amira M. El-kosasy

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0003-2670)

Published

1998

Language

EN

Field

Chemistry (Physical Sciences)