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Gut‐brain axis dysfunction underlies FODMAP‐induced symptom generation in irritable bowel syndrome by Jie Wu; Imke Masuy; Jessica R Biesiekierski; Heather E Fitzke; Chinar Parikh; Laurel Schofield; Hafsa Shaikh; Anisha Bhagwanani; Qasim Aziz; Stuart A Taylor; Jan Tack; Lukas Van Oudenhove is a Medicine article available to read on EtoBox.

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## Summary ## Background FODMAPs produce similar small bowel water and colonic gas in patients with irritable bowel syndrome (IBS) and healthy controls (HCs), despite IBS patients reporting increased gastrointestinal (GI) symptoms. ## Aim To unravel the mechanisms underlying FODMAP‐induced symptom reporting, we investigated gut and brain responses to fructan administration in IBS patients and HC. ## Methods This randomised, double‐blind, cross‐over study consisted of three visits where fructans (40 g/500 mL saline), glucose (40 g/500 mL saline) or saline (500 mL) were infused intragastrically during 1 h MR brain scanning; abdominal MRI was performed before, 1 h, and 2 h post‐infusion. Symptoms were rated using validated scales. ## Results In IBS (n = 13), fructans induced more cramps, pain, flatulence and nausea compared to glucose (P = 0.03, 0.001, 0.009 and 0.14), with between‐group differences for cramps and nausea (P = 0.004 and 0.023). Fructans increased small bowel motility and ascending colonic gas and volume equally in IBS and HC (between‐group P > 0.25). The difference in colonic gas between fructans and saline covaried with differences in bloating and cramps in IBS (P =

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Author

Jie Wu; Imke Masuy; Jessica R Biesiekierski; Heather E Fitzke; Chinar Parikh; Laurel Schofield; Hafsa Shaikh; Anisha Bhagwanani; Qasim Aziz; Stuart A Taylor; Jan Tack; Lukas Van Oudenhove

Publisher

Wiley

Published

2022

Language

EN

Field

Medicine (Health Sciences)