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Gap Junctional Communication via Connexin43 between Purkinje Fibers and Working Myocytes Explains the Epicardial Activation Pattern in the Postnatal Mouse Left Ventricle by Veronika Olejnickova; Matej Kocka; Alena Kvasilova; Hana Kolesova; Adam Dziacky; Tom Gidor; Lihi Gidor; Barbora Sankova; Martina Gregorovicova; Robert G. Gourdie; David Sedmera is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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The mammalian ventricular myocardium forms a functional syncytium due to flow of electrical current mediated in part by gap junctions localized within intercalated disks. The connexin (Cx) subunit of gap junctions have direct and indirect roles in conduction of electrical impulse from the cardiac pacemaker via the cardiac conduction system (CCS) to working myocytes. Cx43 is the dominant isoform in these channels. We have studied the distribution of Cx43 junctions between the CCS and working myocytes in a transgenic mouse model, which had the His-Purkinje portion of the CCS labeled with green fluorescence protein. The highest number of such connections was found in a region about one-third of ventricular length above the apex, and it correlated with the peak proportion of Purkinje fibers (PFs) to the ventricular myocardium. At this location, on the septal surface of the left ventricle, the insulated left bundle branch split into the uninsulated network of PFs that continued to the free wall anteriorly and posteriorly. The second peak of PF abundance was present in the ventricular apex. Epicardial activation maps correspondingly placed the site of the first activation in the apical r

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Author

Veronika Olejnickova; Matej Kocka; Alena Kvasilova; Hana Kolesova; Adam Dziacky; Tom Gidor; Lihi Gidor; Barbora Sankova; Martina Gregorovicova; Robert G. Gourdie; David Sedmera

Publisher

MDPI AG

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)