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This study investigates the binding properties of solasonine, a steroidal glycoalkaloid, to mortalin and p53, and its effects on human hepatocellular carcinoma (HCC) cell lines HepG2 and Hep3b. In silico analysis identified solasonine as a potent inhibitor of mortalin-p53 interactions, leading to p53 translocation to the nucleus and subsequent apoptosis in both cell lines, indicating p53-dependent and independent pathways. The findings suggest solasonine as a promising candidate for HCC treatment through it
- Author
- saurabhchoudhary0701
- Language
- EN