Opening book details…
Can I read Lack of association between stretch‐activated and volume‐activated Cl^−^ currents in hepatocellular carcinoma cells on EtoBox?
Lack of association between stretch‐activated and volume‐activated Cl^−^ currents in hepatocellular carcinoma cells by Jianwen Mao; Bin Xu; Hongzhi Li; Lixin Chen; Xiaobao Jin; Jiayong Zhu; Weizhang Wang; Linyan Zhu; Wanhong Zuo; Weiqiang Chen; Liwei Wang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Lack of association between stretch‐activated and volume‐activated Cl^−^ currents in hepatocellular carcinoma cells about?
Stretch-activated chloride currents (I Cl,SA ) have been considered to be a component of volume-activated chloride currents (I Cl,vol ) for some time. This is due to a similarity in biophysical and pharmacological properties that involve a membrane curvature-induced mechanism and rearrangement of the cytoskeleton induced by cell swelling or membrane stretch. In the present study, we demonstrated that current density, along with the time taken from the activation of currents to the peak, were significantly different between the two currents, in highly metastatic human hepatocellular carcinoma cells. In addition, the activation of I Cl,vol or I Cl,SA , induced maximally by hypotonic solutions or membrane stretch, respectively, did not affect the following activation of the other one. Moreover, neither inhibition of I Cl,vol by sh-ClC-3 transfection, nor functional blocking of I Cl,vol by intracellular dialysis of anti-ClC-3 antibody had an effect on the activation and properties of I Cl,SA . Collectively, our results suggest that I Cl,SA is different from I Cl,vol in activation mechanism and/or in molecular entity responsible for formation of the currents. ClC-3 is involved in the ac
Who reads Lack of association between stretch‐activated and volume‐activated Cl^−^ currents in hepatocellular carcinoma cells?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Jianwen Mao; Bin Xu; Hongzhi Li; Lixin Chen; Xiaobao Jin; Jiayong Zhu; Weizhang Wang; Linyan Zhu; Wanhong Zuo; Weiqiang Chen; Liwei Wang
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0021-9541)
- Published
- 2011
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)