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Asymmetric synthesis of (R)-(+)-[[(2-bromoethyl)amino]methyl]-2-nitro-1H-imidazole-[1-14C]-ethanol monohydrobromide by I. Victor Ekhato is a Medicine article available to read on EtoBox.

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SUMMARY The enantioselective synthesis of \((R)-(+)-2-(\) tert-butyldiphenylsiloxylmethyl \()\left[{ }^{14} \mathrm{C}\right]\) oxirane from \({ }^{14} \mathrm{C}\)-labeled barium carbonate was accomplished. This labeled oxirane facilitated an asymmetric synthesis \((R)-(+)\)-[[(2-bromoethyl)amino]methyl]-2-nitro-1 \(\mathrm{H}\)-imidazole-[ \(\left[1-{ }^{14} \mathrm{C}\right]\)-ethanol monohydrobromide (CI-1010), a potent hypoxic cell selective radiosensizing anti-cancer agent. From labeled barium carbonate the labeled oxirane was prepared in \(26.2 \%\) yield, and this gave the target labeled CI-1010 in \(17 \%\) yield.

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Author

I. Victor Ekhato

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-2135)

Published

1998

Field

Medicine (Life Sciences)