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Localization of tissue inhibitor of metalloproteinases 1 (TIMP‐1) in human colorectal adenoma and adenocarcinoma by Mads N. Holten‐Andersen; Ulla Hansen; Nils Brünner; Hans Jørgen Nielsen; Martin Illemann; Boye Schnack Nielsen is a Medicine article available to read on EtoBox.
What is Localization of tissue inhibitor of metalloproteinases 1 (TIMP‐1) in human colorectal adenoma and adenocarcinoma about?
## Abstract Tissue inhibitor of matrix metalloproteases 1 (TIMP‐1) inhibits the proteolytic activity of matrix metalloproteases and hereby prevents cancer invasion. However, TIMP‐1 also possesses other functions such as inhibition of apoptosis, induction of malignant transformation and stimulation of cell‐growth. We have previously demonstrated that TIMP‐1 is elevated in blood from colorectal cancer patients and that high TIMP‐1 levels predict poor prognosis. To clarify the role of TIMP‐1 in colorectal tumorigenesis, the expression pattern of TIMP‐1 in benign and malignant colorectal tumors was studied. In all of 24 cases of colorectal adenocarcinoma TIMP‐1 mRNA was detected by __in situ__ hybridization. In all cases TIMP‐1 expression was found in fibroblast‐like cells located at the invasive front but was seen only sporadically in normal mucosa. No TIMP‐1 mRNA was seen in any of the cases in benign or malignant epithelial cells, in vascular cells or smooth muscle cells. Comparison of sections processed for TIMP‐1 __in situ__ hybridization with sections immunohistochemically stained with antibodies against TIMP‐1 showed good correlation between TIMP‐1 mRNA and immunoreactivity. Com
Who reads Localization of tissue inhibitor of metalloproteinases 1 (TIMP‐1) in human colorectal adenoma and adenocarcinoma?
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- Author
- Mads N. Holten‐Andersen; Ulla Hansen; Nils Brünner; Hans Jørgen Nielsen; Martin Illemann; Boye Schnack Nielsen
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2004
- Language
- EN
- Field
- Medicine (Health Sciences)