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Androgen Deprivation Therapy Does Not Impact Cause-Specific or Overall Survival in High-Risk Prostate Cancer Managed With Brachytherapy and Supplemental External Beam by Gregory S. Merrick; Wayne M. Butler; Kent E. Wallner; Robert W. Galbreath; Zachariah A. Allen; Edward Adamovich; Jonathan Lief is a Medicine article available to read on EtoBox.

What is Androgen Deprivation Therapy Does Not Impact Cause-Specific or Overall Survival in High-Risk Prostate Cancer Managed With Brachytherapy and Supplemental External Beam about?

Purpose: To determine cause-specific survival (CSS), biochemical progression-free survival (bPFS), and overall survival (OS) in high-risk prostate cancer patients undergoing brachytherapy with or without supplemental therapies. Methods and Materials: Between April 1995 and July 2002, 204 patients with high-risk prostate cancer (Gleason score >8 or prostate-specific antigen [PSA] >20 ng/mL or clinical stage >T2c) underwent brachytherapy. Median follow-up was 7.0 years. The bPFS was defined by a PSA <0.40 ng/mL after nadir. Multiple clinical, treatment, and dosimetric parameters were evaluated for the impact on survival. Results: The 10-year CSS, bPFS, and OS were 88.9%, 86.6%, and 68.6%, respectively. A statistically significant difference in bPFS was discerned between hormone naive, ADT 6 month cohorts (79.7% vs. 95.% vs. 89.9%, p ‫؍‬ 0.032). Androgen deprivation therapy (ADT) did not impact CSS or OS. For bPFS patients, the median posttreatment PSA was <0.04 ng/mL. A Cox linear regression analysis demonstrated that Gleason score was the best predictor of CSS, whereas percent positive biopsies and duration of ADT best predicted for bPFS. The OS was best predicted by Gleason score

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Author

Gregory S. Merrick; Wayne M. Butler; Kent E. Wallner; Robert W. Galbreath; Zachariah A. Allen; Edward Adamovich; Jonathan Lief

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2007

Language

EN

Field

Medicine (Health Sciences)