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Characterization and Clinical Association of Autoantibodies Against Perilipin 1 in Patients With Acquired Generalized Lipodystrophy by Fernando Corvillo; Brent S. Abel; Alberto López-Lera; Giovanni Ceccarini; Silvia Magno; Ferruccio Santini; David Araújo-Vilar; Rebecca J. Brown; Pilar Nozal; Margarita López-Trascasa is a Medicine article available to read on EtoBox.
What is Characterization and Clinical Association of Autoantibodies Against Perilipin 1 in Patients With Acquired Generalized Lipodystrophy about?
Acquired generalized lipodystrophy (AGL) is a rare condition characterized by massive loss of adipose tissue through the body, causing severe metabolic complications. Autoimmune destruction of adipocytes is strongly suspected based on the frequent association of AGL with autoimmune disorders. In 2018, autoantibodies against perilipin 1 (PLIN1) were identified in three patients with autoimmune-associated AGL. However, the pathogenic mechanism and clinical impact of anti-PLIN1 remain unsolved. The prevalence of anti-PLIN1 autoantibodies in an AGL cohort of 40 patients was 50% (20 of 40). Among positive patients, 10 had the autoimmune variety and 10 had panniculitis-associated AGL. The IgG isotype was predominant, although some IgM antibodies were detected. Epitope-mapping studies did not identify a single, major epitope. Instead, autoantibodies typically bound to several different peptides, among which the central (233-405) domain was detected in all antibody-positive patients, for both IgG and IgM autoantibodies. In-depth epitope mapping indicated that anti-PLIN1 autoantibodies predominantly recognize the ab-hydrolase domain containing 5 (ABHD5) binding site . Autoantibodies dosedep
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- Author
- Fernando Corvillo; Brent S. Abel; Alberto López-Lera; Giovanni Ceccarini; Silvia Magno; Ferruccio Santini; David Araújo-Vilar; Rebecca J. Brown; Pilar Nozal; Margarita López-Trascasa
- Publisher
- American Diabetes Association
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)