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Combinations of Olmesartan and a Calcium Channel Blocker or a Diuretic in Elderly Hypertensive Patients: a Randomized, Controlled Trial^1^ by Toshio Ogihara; Takao Saruta; Hiromi Rakugi; Ikuo Saito; Kazuaki Shimamoto; Hiroaki Matsuoka; Kazuyuki Shimada; Sadayoshi Ito; Masatsugu Horiuchi; Tsutomu Imaizumi; Shuichi Takishita; Jitsuo Higaki; Shigehiro Katayama; Genjiroh Kimura; Satoshi Umemura; Nobuyuki Ura; Koichi Hayashi; Masato Odawara; Norio Tanahashi; Toshihiko Ishimitsu; Naoki Kashihara; Satoshi Morita; Satoshi Teramukai is a Medicine article available to read on EtoBox.

What is Combinations of Olmesartan and a Calcium Channel Blocker or a Diuretic in Elderly Hypertensive Patients: a Randomized, Controlled Trial^1^ about?

## Objective: The aim of the present study was to compare the cardiovascular effects of olmesartan, an angiotensin II receptor blocker, combined with a calcium channel blocker (CCB) or a diuretic, in a prospective, randomized, open-label, blinded endpoint trial. ## Methods: Japanese hypertensive patients aged at least 65 to less than 85 years with SBP at least 140 mmHg and/or DBP at least 90 mmHg with antihypertensive treatment, or SBP at least 160 mmHg and/or DBP at least 100 mmHg without antihypertensive treatment were randomized to receive olmesartan with either a dihydropyridine CCB or a low-dose diuretic. If SBP and/or DBP remained at least 140 and/or at least 90 mmHg, the other antihypertensive drug was added. The primary endpoint was a composite of fatal and nonfatal cardiovascular events. The median follow-up time was 3.3 years. ## Results: Blood pressure decreased similarly in both groups. The primary endpoint occurred in 116/2568 patients (4.5%) in the olmesartan plus CCB group and in 135/2573 patients (5.3%) in the olmesartan plus diuretic group [hazard ratio 0.83, 95% confidence interval (CI) 0.65–1.07, __P__ = 0.16]. Rates of all-cause death and cardiovascular deaths w

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Author

Toshio Ogihara; Takao Saruta; Hiromi Rakugi; Ikuo Saito; Kazuaki Shimamoto; Hiroaki Matsuoka; Kazuyuki Shimada; Sadayoshi Ito; Masatsugu Horiuchi; Tsutomu Imaizumi; Shuichi Takishita; Jitsuo Higaki; Shigehiro Katayama; Genjiroh Kimura; Satoshi Umemura; Nobuyuki Ura; Koichi Hayashi; Masato Odawara; Norio Tanahashi; Toshihiko Ishimitsu; Naoki Kashihara; Satoshi Morita; Satoshi Teramukai

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2014

Language

EN

Field

Medicine (Health Sciences)