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The major histocompatibility complex-restricted antigen receptor on T cells: Distribution on thymus and peripheral T cells by Neal Roehm; Lynne Herron; John Cambier; David Diguisto; Kathryn Haskins; John Kappler; Philippa Marrack is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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A monoclonal antibody, KJ16-133, which binds to antigen-specific, major histocompatibility complex-restricted (Ag/MHC) receptors on about 20% of BALB/c peripheral T cells has been used to examine the expression of these receptors on thymocytes and different subpopulations of peripheral T cells. Although KJ16-133-reactive receptors were found on mature thymocytes at similar frequencies and levels as on peripheral T cells, these molecules were absent from the first cells to enter the thymus, and in less mature thymocyte populations KJ16-133-reactive cells were less frequent than in the periphery and bore lower quantities of receptor. These results showed that Ag/MHC receptors are present on the surfaces of immature thymocytes, albeit at variable levels, during the time that the repertoire of these cells for Ag/MHC is thought to be selected. Additional experiments showed that KJ16-133 could not be used to distinguish T-cell receptors with different restriction specificities, i.e., for Class I or Class II products of the MHC.

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Author

Neal Roehm; Lynne Herron; John Cambier; David Diguisto; Kathryn Haskins; John Kappler; Philippa Marrack

Published

1984

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)