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Determination of Perfluorinated Carboxylic Acids in Biological Samples by High-performance Liquid Chromatography by Takeshi Ohya; Naomi Kudo; Erika Suzuki; Yoichi Kawashima is a Chemistry article available to read on EtoBox.

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This paper describes a method for the quantitative determination of perfluorinated carboxylic acids (PFCAs), perfluorohexanoic acid (C6-PFCA), perfluoroheptanoic acid (C7-PFCA), perfluorooctanoic acid (C8-PFCA), perfluorononanoic acid (C9-PFCA) and perfluorodecanoic acid (C10-PFCA), in biological samples. PFCA in liver homogenates was extracted as an ion pair with tetrabutylammonium (TBA) ion into organic solvent, then the PFCA was derivatized with 3-bromoacetyl-7methoxycoumarin (BrAMC) and quantified by HPLC with fluorescence detection. This method is applicable for the studies on tissue accumulation and elimination of PFCAs in animals after the administration.

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Author

Takeshi Ohya; Naomi Kudo; Erika Suzuki; Yoichi Kawashima

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-4347)

Published

1998

Language

EN

Field

Chemistry (Physical Sciences)