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Developmental Regulation of Synaptic Mechanisms That May Contribute to Learning and Memory by Laura Schrader; Michael J. Friedlander is a Medicine article available to read on EtoBox.

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The cerebral cortex is able to undergo dramatic adaptive functional changes in response to a variety of challenges such as sensory experience, patterned vs. chaotic environmental cues, training, learning, and peripheral or central nervous system injury. The period of early postnatal development is particularly conducive to such changes although the adult cortex can also exhibit robust plasticity. A major site of these forms of adaptive changes is the cortical synapse. In this study, we examine the ability of cerebral cortical synapses, particularly in the visual cortex, to undergo changes in their functional strength in response to a particular model of synaptic learning-the covariance or BCM model. This model incorporates the demand for incoming synaptic activity and the level of activation of a target or postsynaptic neuron to correlate or covary. A dramatic switch in the underlying cellular signaling mechanism for this form of synaptic plasticity occurs during postnatal development. The neurotransmitter receptor mechanism that triggers the plasticity switches from one mediated by metabotropic glutamate receptors to a NMDA glutamate receptor-mediated process. The implications of

Who reads Developmental Regulation of Synaptic Mechanisms That May Contribute to Learning and Memory?

Author

Laura Schrader; Michael J. Friedlander

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1080-4013)

Published

1999

Language

EN

Field

Medicine (Life Sciences)