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HLA‐DRB1\*1501 risk association in multiple sclerosis may not be related to presentation of myelin epitopes by Thomas P. Finn; Richard E. Jones; Cathleen Rich; Rony Dahan; Jason Link; Chella S. David; Yuan K. Chou; Halina Offner; Arthur A. Vandenbark is a Neuroscience article available to read on EtoBox.

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## Abstract Susceptibility to multiple sclerosis (MS) is associated genetically with human leucocyte antigen (HLA) class II alleles, including DRB1\*1501, DRB5\*0101, and DQB1\*0602, and it is possible that these alleles contribute to MS through an enhanced ability to present encephalitogenic myelin peptides to pathogenic T cells. HLA‐DRB1\*1502, which contains glycine instead of valine at position 86 of the P1 peptide‐binding pocket, is apparently not genetically associated with MS. To identify possible differences between these alleles in their antigen‐presenting function, we determined if T‐cell responses to known DRB1\*1501‐restricted myelin peptides might be diminished or absent in transgenic (Tg) DRB1\*1502‐expressing mice. We found that Tg DRB1\*1502 mice had moderate to strong T‐cell responses to several myelin peptides with favorable DRB1\*1501 binding motifs, notably myelin oligodendrocyte glycoprotein (MOG)‐35‐55 (which was also encephalitogenic), proteolipid protein (PLP)‐95‐116, and MOG‐194‐208, as well as other PLP and MOG peptides. These peptides, with the exception of MOG‐194‐208, were also immunogenic in healthy human donors expressing either DRB1\*1502 or DRB1\*15

Who reads HLA‐DRB1\*1501 risk association in multiple sclerosis may not be related to presentation of myelin epitopes?

Author

Thomas P. Finn; Richard E. Jones; Cathleen Rich; Rony Dahan; Jason Link; Chella S. David; Yuan K. Chou; Halina Offner; Arthur A. Vandenbark

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)

Published

2004

Language

EN

Field

Neuroscience (Life Sciences)