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Brain areas involved in medial temporal lobe seizures: A principal component analysis of ictal SPECT data by Bruno J. Weder; Kaspar Schindler; Thomas J. Loher; Roland Wiest; Michael Wissmeyer; Peter Ritter; Karl Lovblad; Filippo Donati; John Missimer is a Neuroscience article available to read on EtoBox.
What is Brain areas involved in medial temporal lobe seizures: A principal component analysis of ictal SPECT data about?
## Abstract The study describes brain areas involved in medial temporal lobe (mTL) seizures of 12 patients. All patients showed so‐called oro‐alimentary behavior within the first 20 s of clinical seizure manifestation characteristic of mTL seizures. Single photon emission computed tomography (SPECT) images of regional cerebral blood flow (rCBF) were acquired from the patients in ictal and interictal phases and from normal volunteers. Image analysis employed categorical comparisons with statistical parametric mapping and principal component analysis (PCA) to assess functional connectivity. PCA supplemented the findings of the categorical analysis by decomposing the covariance matrix containing images of patients and healthy subjects into distinct component images of independent variance, including areas not identified by the categorical analysis. Two principal components (PCs) discriminated the subject groups: patients with right or left mTL seizures and normal volunteers, indicating distinct neuronal networks implicated by the seizure. Both PCs were correlated with seizure duration, one positively and the other negatively, confirming their physiological significance. The independen
Who reads Brain areas involved in medial temporal lobe seizures: A principal component analysis of ictal SPECT data?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Bruno J. Weder; Kaspar Schindler; Thomas J. Loher; Roland Wiest; Michael Wissmeyer; Peter Ritter; Karl Lovblad; Filippo Donati; John Missimer
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 1065-9471)
- Published
- 2005
- Language
- EN
- Field
- Neuroscience (Life Sciences)