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Can I read Dearomative (3 + 2) Cycloadditions of Unprotected Indoles on EtoBox?
Dearomative (3 + 2) Cycloadditions of Unprotected Indoles by Bram Ryckaert; Jan Hullaert; Kristof Van Hecke; Johan M. Winne is a Chemistry article available to read on EtoBox.
What is Dearomative (3 + 2) Cycloadditions of Unprotected Indoles about?
The (3 + 2) cycloaddition of various indoles with a dithioallyl cation affords dearomatized cyclopentannulated adducts, with complete control of regioselectivity and excellent chemo- and diastereoselectivity. The success of the reaction critically relies on the use of an excess of very strong Brønsted acid, which paradoxically prevents carbocationic side reactions. The reaction tolerates sensitive functionalities such as basic amines or free hydroxyls, and we demonstrate its use in late stage derivatization of highly functionalized, unprotected indoles.
Who reads Dearomative (3 + 2) Cycloadditions of Unprotected Indoles?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Bram Ryckaert; Jan Hullaert; Kristof Van Hecke; Johan M. Winne
- Publisher
- American Chemical Society (ACS)
- Published
- 2022
- Language
- EN
- Field
- Chemistry (Physical Sciences)
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