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Can I read Design, Synthesis and Biological Investigation of Certain Pyrazole-3-carboxylic Acid Derivatives as Novel Carriers for Nitric Oxide on EtoBox?
Design, Synthesis and Biological Investigation of Certain Pyrazole-3-carboxylic Acid Derivatives as Novel Carriers for Nitric Oxide by El-Shimaa M.N. Abdel-Hafez; Gamal El-Din A.A. Abuo-Rahma; Mohamed Abdel-Aziz; Mohamed F. Radwan; Hassan H. Farag is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Design, Synthesis and Biological Investigation of Certain Pyrazole-3-carboxylic Acid Derivatives as Novel Carriers for Nitric Oxide about?
Some novel pyrazole-NO hybrid molecules 5a-e, 6, 8 and 10 were prepared through binding of the pyrazole-3-carboxylic acid derivatives with nitric oxide donor moiety like oxime or nitrate ester. The prepared compounds were evaluated for nitric oxide release, antibacterial and anti-inflammatory activities. The organic nitrate 10 exhibited the highest percentage of NO release using Griess diazotization method. Some of the prepared compounds exhibited remarkable antibacterial activity against Escherichia coli C-600, Pseudomonas aeruginosa, Bacillus subitilis and Staphylococcus aureus NCTC 6571 compared to ciprofloxacin. Most of the tested compounds showed significant anti-inflammatory activity compared to indomethacine using carrageenan induced paw edema method. In general, structural modification of compound 2 either to nitrate ester or oxime hybrids showed better anti-inflammatory with less ulcerogenic liability than their corresponding starting intermediates.
Who reads Design, Synthesis and Biological Investigation of Certain Pyrazole-3-carboxylic Acid Derivatives as Novel Carriers for Nitric Oxide?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- El-Shimaa M.N. Abdel-Hafez; Gamal El-Din A.A. Abuo-Rahma; Mohamed Abdel-Aziz; Mohamed F. Radwan; Hassan H. Farag
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)
- Published
- 2009
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)