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Can I read Terminal complement pathway activation drives synaptic loss in Alzheimer’s disease models on EtoBox?
Terminal complement pathway activation drives synaptic loss in Alzheimer’s disease models by Sarah M. Carpanini; Megan Torvell; Ryan J. Bevan; Robert A. J. Byrne; Nikoleta Daskoulidou; Takashi Saito; Takaomi C. Saido; Philip R. Taylor; Timothy R. Hughes; Wioleta M. Zelek; B. Paul Morgan is a Medicine article available to read on EtoBox.
What is Terminal complement pathway activation drives synaptic loss in Alzheimer’s disease models about?
Complement is involved in developmental synaptic pruning and pathological synapse loss in Alzheimer's disease. It is posited that C1 binding initiates complement activation on synapses; C3 fragments then tag them for microglial phagocytosis. However, the precise mechanisms of complement-mediated synaptic loss remain unclear, and the role of the lytic membrane attack complex (MAC) is unexplored. We here address several knowledge gaps: (i) is complement activated through to MAC at the synapse? (ii) does MAC contribute to synaptic loss? (iii) can MAC inhibition prevent synaptic loss? Novel methods were developed and optimised to quantify C1q, C3 fragments and MAC in total and regional brain homogenates and synaptoneurosomes from WT and App Alzheimer's disease model mouse brains at 3, 6, 9 and 12 months of age. The impact on synapse loss of systemic treatment with a MAC blocking antibody and gene knockout of a MAC component was assessed in Alzheimer's disease model mice. A significant increase in C1q, C3 fragments and MAC was observed in App mice compared to controls, increasing with age and severity. Administration of anti-C7 antibody to App mice modulated synapse loss, reflected by t
Who reads Terminal complement pathway activation drives synaptic loss in Alzheimer’s disease models?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Sarah M. Carpanini; Megan Torvell; Ryan J. Bevan; Robert A. J. Byrne; Nikoleta Daskoulidou; Takashi Saito; Takaomi C. Saido; Philip R. Taylor; Timothy R. Hughes; Wioleta M. Zelek; B. Paul Morgan
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)