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Can I read Review article: the efficacy of infliximab in Crohn’s disease — healing of fistulae on EtoBox?
Review article: the efficacy of infliximab in Crohn’s disease — healing of fistulae by D.H. Present is a Medicine article available to read on EtoBox.
What is Review article: the efficacy of infliximab in Crohn’s disease — healing of fistulae about?
In the management of fistulae, the current therapeutic approach is the use of a combination of antibiotics and/or a combination of immunomodulatory agents. However, clinicians treating patients with fistulae, particularly those with fistulizing Crohn’s disease, have little data from controlled clinical trials of these pharmacologic agents or regimens to substantiate their use in treating this complication. Therapy with the anti‐tumour necrosis factor‐alpha antibody, infliximab, has shown promise in treating patients with Crohn’s disease and those with the disease complicated by fistulae. A recent clinical trial was designed specifically to evaluate infliximab in the treatment of fistulizing Crohn’s disease. Study results demonstrated infliximab to be the first therapeutic agent to show statistical efficacy in fistulae closure in a placebo‐controlled trial. Therapy with the chimeric monoclonal antibody was characterized by a rapid onset of closure and a lasting benefit of action. Two patient cases from the clinical trial are presented to exemplify the dramatic effectiveness of this novel therapeutic approach in modulating the immune response of patients with this debilitating compli
Who reads Review article: the efficacy of infliximab in Crohn’s disease — healing of fistulae?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- D.H. Present
- Publisher
- John Wiley and Sons; Blackwell Publishing; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0269-2813)
- Published
- 1999
- Language
- EN
- Field
- Medicine (Health Sciences)