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Massive inflammatory syndrome and lymphocytic immunodeficiency in KARAP/DAP12-transgenic mice by Mathias Lucas; Laurent Daniel; Elena Tomasello; Sophie Guia; Nicole Horschowski; Naoko Aoki; Dominique Figarella-Branger; Sophie Gomez; Eric Vivier is a Immunology and Microbiology article available to read on EtoBox.

What is Massive inflammatory syndrome and lymphocytic immunodeficiency in KARAP/DAP12-transgenic mice about?

KARAP/DAP12 is a broadly distributed transmembrane signaling polypeptide with an immunoreceptor tyrosine-based activation motif, and is non-covalently associated with a variety of activating surface receptors. We report here the characterization of transgenic mice that overexpress KARAP/DAP12 polypeptides in both myeloid and lymphoid compartments. KARAP/DAP12-transgenic mice present, in a transgene dose-dependent manner, a complex phenotype characterized by two independent and spontaneous hematological abnormalities: (i) a severe lymphopenia and (ii) a massive inflammatory syndrome associated with neutrophilia and lung infiltration by multinucleated macrophages. These myeloid abnormalities observed in KARAP/DAP12-transgenic mice indicate that KARAP/DAP12-driven signals are critically involved in inflammation, and constitute an essential target to control the resolution of inflammatory disorders based on monocytes/macrophages and neutrophils.

Who reads Massive inflammatory syndrome and lymphocytic immunodeficiency in KARAP/DAP12-transgenic mice?

Author

Mathias Lucas; Laurent Daniel; Elena Tomasello; Sophie Guia; Nicole Horschowski; Naoko Aoki; Dominique Figarella-Branger; Sophie Gomez; Eric Vivier

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 0014-2980)

Published

2002

Language

EN

Field

Immunology and Microbiology (Life Sciences)