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Can I read A Tumor Homing Peptide-Conjugated Poly(epsilon-lysine) Delivery System for Improved Antitumor Drug Loading and Targeting on EtoBox?
A Tumor Homing Peptide-Conjugated Poly(epsilon-lysine) Delivery System for Improved Antitumor Drug Loading and Targeting by Shafq Al-azzawi; Dhafir Masheta is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is A Tumor Homing Peptide-Conjugated Poly(epsilon-lysine) Delivery System for Improved Antitumor Drug Loading and Targeting about?
The main challenges with conventional chemotherapeutic drugs are their non-selective toxicity and limited targeting abilities. Hence, it is imperative to employ a specific targeting drug delivery system (DDS) to improve their specificity with a potential activity. This study aims to enhance antitumor delivery, loading and targeting via functionalization of a poly lysine carrier system with a tumor-homing peptide, CREKA. Solid phase peptide synthesis was employed in the synthesis, and mass spectra and HPLC techniques were used for characterization. The cytotoxicity on tumor and normal cells was assessed via a cell viability test and degradation rate with cellular uptake by confocal microscopy and flow cytometry were also studied. Biochemical enzymatic inhibition assay on dihydrofolate reductase (DHFR), the target enzyme, was conducted to study the efficacy of the drug-loaded DDS. The results confirmed successful synthesis and conjugation of the drug with this DDS with high effectiveness against cytotoxicity and inhibition of DHFR. Results also revealed a high degradation rate at the acidic pH and cellular internalization. It can be concluded that the CREKA-functionalized DDS has del
Who reads A Tumor Homing Peptide-Conjugated Poly(epsilon-lysine) Delivery System for Improved Antitumor Drug Loading and Targeting?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Shafq Al-azzawi; Dhafir Masheta
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)