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Analysis of Oral Microbiota in Patients with Obstructive Sleep Apnea-associated Hypertension by Chih-Yuan Ko; An-Ke Hu; Dylan Chou; Li-Mei Huang; Huan-Zhang Su; Fu-Rong Yan; Xiao-Bin Zhang; Hua-Ping Zhang; Yi-Ming Zeng is a Medicine article available to read on EtoBox.
What is Analysis of Oral Microbiota in Patients with Obstructive Sleep Apnea-associated Hypertension about?
Obstructive sleep apnea–hypopnea syndrome (OSAHS) is an independent risk factor for hypertension (HTN). The oral microbiota plays a pathophysiological role in cardiovascular diseases; however, there are few reports directly investigating and identifying the organisms involved in OSAHS-related HTN. Therefore, this study aimed to identify those organisms. We obtained 139 oral samples and determined the microbiome composition using pyrosequencing and bioinformatic analyses of the 16S rRNA. We examined the fasting levels of cytokines and homocysteine in all participants and analyzed the correlations between the oral microbiota and homocysteine levels. We determined the molecular mechanism underlying HTN by investigating the genetic composition of the strains in the blood. We detected higher relative abundances of __Porphyromonas__ and __Aggregatibacter__ and elevated proinflammatory cytokines in patients with OSAHS of varying severity compared with individuals without OSAHS; however, the two organisms were not measured in the blood samples from all participants. High levels of specific __Porphyromonas__ bacteria were detected in patients with OSAHS with and without HTN, whereas the rel
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- Author
- Chih-Yuan Ko; An-Ke Hu; Dylan Chou; Li-Mei Huang; Huan-Zhang Su; Fu-Rong Yan; Xiao-Bin Zhang; Hua-Ping Zhang; Yi-Ming Zeng
- Publisher
- Nature Publishing Group; Springer Science and Business Media LLC; Japanese Society of Hypertension; Springer Nature (ISSN 0916-9636)
- Published
- 2019
- Language
- EN
- Field
- Medicine (Health Sciences)