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Paediatric sepsis-associated encephalopathy (SAE): a comprehensive review by John Sieh Dumbuya; Siqi Li; Lili Liang; Qiyi Zeng is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Paediatric sepsis-associated encephalopathy (SAE): a comprehensive review about?

Abstract Sepsis-associated encephalopathy (SAE) is one of the most common types of organ dysfunction without overt central nervous system (CNS) infection. It is associated with higher mortality, low quality of life, and long-term neurological sequelae, its mortality in patients diagnosed with sepsis, progressing to SAE, is 9% to 76%. The pathophysiology of SAE is still unknown, but its mechanisms are well elaborated, including oxidative stress, increased cytokines and proinflammatory factors levels, disturbances in the cerebral circulation, changes in blood–brain barrier permeability, injury to the brain’s vascular endothelium, altered levels of neurotransmitters, changes in amino acid levels, dysfunction of cerebral microvascular cells, mitochondria dysfunction, activation of microglia and astrocytes, and neuronal death. The diagnosis of SAE involves excluding direct CNS infection or other types of encephalopathies, which might hinder its early detection and appropriate implementation of management protocols, especially in paediatric patients where only a few cases have been reported in the literature. The most commonly applied diagnostic tools include electroencephalography, neur

Who reads Paediatric sepsis-associated encephalopathy (SAE): a comprehensive review?

Author

John Sieh Dumbuya; Siqi Li; Lili Liang; Qiyi Zeng

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)