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P-039 Composite Pp/plla Monofilament 4dventral® Promotes An Anti-inflammatory Response From Human Macrophages In Vitro by M Daoudi; A Myslakowski; K Abechir; A Carton; S Ouerghemmi; M Caillibotte; P Thomas is a Medicine article available to read on EtoBox.

What is P-039 Composite Pp/plla Monofilament 4dventral® Promotes An Anti-inflammatory Response From Human Macrophages In Vitro about?

Abstract The repair of abdominal hernias with prosthetic mesh can significantly reduce the risk of hernia recurrence. A new type of hernia implants combines monofilaments, Polypropylene (PP) and a biobased and natural slowly bioabsorbable polymer, Poly-L-Lactic Acid (PLLA). The partially (60%) resorbable PLLA/PP and PP meshes manufactured by COUSIN Surgery are 4DVentral® and Biomesh P1®. The contribution of PLLA in regulated inflammatory response and in enhancing abdominal repair remains unknown. Inflammation has a functional role during tissue regeneration process. An abnormal macrophage response characterized by an uncontrolled release of pro-inflammatory cytokines, chemokines, and tissue-degrading enzymes has been shown to be responsible for postoperative complications. In contrast, the angiogenic and tissue remodeling activities of the alternative anti-inflammatory M2 macrophages have potential use in tissue regenerative. Here, the characterization of the inflammatory response of human macrophages in vitro regarding 4DVentral® compared to Biomesh P1® was performed. Human monocytic THP-1 cells were differentiated into macrophages and polarized in M1 macrophages by incubation wit

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Author

M Daoudi; A Myslakowski; K Abechir; A Carton; S Ouerghemmi; M Caillibotte; P Thomas

Published

2022

Language

EN

Field

Medicine (Health Sciences)