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Comparative Spinal Distribution and Clearance Kinetics of Intrathecally Administered Morphine, Fentanyl, Alfentanil, and Sufentanil by Lizeth Chavarro is a document available to read on EtoBox.

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This study investigates the pharmacokinetics of intrathecally administered opioids (morphine, fentanyl, alfentanil, and sufentanil) using a pig model with microdialysis techniques to sample drug concentrations in various spinal compartments. Results indicate that morphine has the highest spinal cord exposure due to its low distribution volume and slow clearance, while the other opioids exhibit different pharmacokinetic behaviors that correlate with their analgesic effects. The findings highlight the need fo

Author

Lizeth Chavarro

Language

EN