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Features of Metabolic Syndrome and Inflammation Independently Affect Left Ventricular Function Early After First Myocardial Infarction by Jan Traub; Paula Schürmann; Dominik Schmitt; Tobias Gassenmaier; Georg Fette; Stefan Frantz; Stefan Störk; Niklas Beyersdorf; Valérie Boivin-Jahns; Roland Jahns; Ulrich Hofmann; Anna Frey is a Medicine article available to read on EtoBox.

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## Background: A high body mass index (bmi) is often associated with metabolic syndrome, which is accompanied by systemic low-grade chronic inflammation. here, we analyzed whether bmi, other components of metabolic syndrome, and/or inflammatory markers correlate with left ventricular geometry, function, and infarct size as assessed by serial cardiac magnetic resonance imaging (mri) after a first (clinically evident) st-elevation mi (stemi). ## Methods: Within the etiology, titre-course, and effect on survival (etics) study, cardiac mri conducted 7-9 days and 12 months after mi enabled longitudinal characterization of patients with a first stemi along with serial routine blood counts and multiplex cytokine measurements. ## Results: Of 91 locally included stemi patients, 47% were overweight (25 kg/m < bmi < 30 kg/m) and 24% were obese (bmi ≥ 30 kg/m). no patient died during 12 months of follow-up. left ventricular ejection fraction (lvef), measured 7-9 days after stemi, was significantly lower in overweight (49.5 ± 7.1%) and obese (45.8 ± 12.0%) patients than in the normal weight group (56.2 ± 7.7%). along with bmi (t = -3.8; p < 0.001), hemoglobin a1c (hba1c; t = -3.1; p = 0.004) an

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Author

Jan Traub; Paula Schürmann; Dominik Schmitt; Tobias Gassenmaier; Georg Fette; Stefan Frantz; Stefan Störk; Niklas Beyersdorf; Valérie Boivin-Jahns; Roland Jahns; Ulrich Hofmann; Anna Frey

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Medicine (Health Sciences)