Can I read Effects of Improved Glycaemic Control on Endothelial Function in Patients with Type 2 Diabetes on EtoBox?

Effects of Improved Glycaemic Control on Endothelial Function in Patients with Type 2 Diabetes by W. Bagg; G. A. Whalley; G. Gamble; P. L. Drury; N. Sharpe; G. D. Braatvedt is a Medicine article available to read on EtoBox.

What is Effects of Improved Glycaemic Control on Endothelial Function in Patients with Type 2 Diabetes about?

## Abstract __Background__: Patients with type 2 diabetes have abnormal endothelial function but it is not certain whether improvements in glycaemic control will improve endothelial function. __Aims__: To examine the effects of short‐term improved glycaemic control on endothelial function in patients with inadequately regulated type 2 diabetes mellitus. __Methods__: Forty‐three patients with type 2 diabetes and glycosylated haemoglobin (HbA~1c~) > 8.9% were randomized to either improved glycaemic control (IC) __n__ = 21 or usual glycaemic control (UC) __n__ = 22 for 20 weeks. Using high‐resolution B‐mode ultrasound, brachial artery flow‐mediated dilatation (FMD) and glyceryl trinitrate‐mediated dilatation (GTN‐D) were measured at baseline and 20 weeks later. __Results__: After 20 weeks, HbA~1c~ was significantly lower in IC versus UC (IC 8.02 ± 0.25% versus UC 10.23 ± 0.23%, __P__ < 0.0001) but changes in FMD and GTN‐D were not different between the groups (FMD at baseline and week 20 IC 5.1 ± 0.56% versus 4.9 ± 0.56% and UC 4.2 ± 0.51% versus 3.1 ± 0.51%; __P__ = 0.23: GTN‐D IC 12.8 ± 1.34% versus 10.4 ± 1.32% and UC 13.7 ± 1.2% versus 12.7 ± 1.23%; __P__ = 0.39). In the IC group

Who reads Effects of Improved Glycaemic Control on Endothelial Function in Patients with Type 2 Diabetes?

Author

W. Bagg; G. A. Whalley; G. Gamble; P. L. Drury; N. Sharpe; G. D. Braatvedt

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1444-0903)

Published

2001

Language

EN

Field

Medicine (Health Sciences)