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Systemic central venous oxygen saturation is associated with clot strength during traumatic hemorrhagic shock: A preclinical observational model by Nathan J White; Erika J Martin; Yongyun Shin; Donald F Brophy; Robert F Diegelmann; Kevin R Ward is a Medicine article available to read on EtoBox.
What is Systemic central venous oxygen saturation is associated with clot strength during traumatic hemorrhagic shock: A preclinical observational model about?
## Background: Clot strength by thrombelastography (teg) is associated with mortality during trauma and has been linked to severity of tissue hypoperfusion. however, the optimal method for monitoring this important relationship remains undefined. we hypothesize that oxygen transport measurements will be associated with clot strength during traumatic shock, and test this hypothesis using a swine model of controlled traumatic shock. ## Methods: N = 33 swine were subjected to femur fracture and hemorrhagic shock by controlled arterial bleeding to a predetermined level of oxygen debt measured by continuous indirect calorimetry. hemodynamics, oxygen consumption, systemic central venous oxygenation (scvo2), base excess, lactate, and clot maximal amplitude by teg (teg-ma) as clot strength were measured at baseline and again when oxygen debt = 80 ml/kg during shock. oxygen transport and metabolic markers of tissue perfusion were then evaluated for significant associations with teg-ma. forward stepwise selection was then used to create regression models identifying the strongest associations between oxygen transport and teg-ma independent of other known determinants of clot strength. ## Res
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- Author
- Nathan J White; Erika J Martin; Yongyun Shin; Donald F Brophy; Robert F Diegelmann; Kevin R Ward
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1757-7241)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)