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Real-world Evidence Comparing Tofacitinib and Vedolizumab in Anti-TNF-experienced Patients With Ulcerative Colitis by Sruthi Adimadhyam; James D Lewis; Andrew L Simon; Audrey E Wolfe; Samantha Smith; Laura Hou; Érick Moyneur; Juliane S Reynolds; Sengwee Toh; Angela Dobes; Lauren Parlett; Kevin Haynes; Jessica Burris; Jennifer E Dorand; Millie D Long; Michael D Kappelman is a Medicine article available to read on EtoBox.

What is Real-world Evidence Comparing Tofacitinib and Vedolizumab in Anti-TNF-experienced Patients With Ulcerative Colitis about?

## Abstract ## Background Antitumor necrosis factor (anti-TNF) inhibitors are first-line treatment among patients with ulcerative colitis (UC). With time, patients tend to lose response or become intolerant, necessitating switching to small cell biologics such as tofacitinib or vedolizumab. In this real-world study of a large, geographically diverse US population of TNF-experienced patients with UC, we evaluated the effectiveness and safety of newly initiating treatment with tofacitinib vs vedolizumab. ## Methods We conducted a cohort study using secondary data from a large US insurer (Anthem, Inc.). Our cohort included patients with UC newly initiating treatment with tofacitinib or vedolizumab. Patients were required to have evidence of treatment with anti-TNF inhibitors in the 6 months prior to cohort entry. The primary outcome was treatment persistence >52 weeks. Additionally, we evaluated the following secondary outcomes as additional measures of effectiveness and safety: (1) all-cause hospitalization; (2) total abdominal colectomy; (3) hospitalization for infection; (4) hospitalization for malignancy; (5) hospitalization for cardiac events; and (6) hospitalization for thromboe

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Author

Sruthi Adimadhyam; James D Lewis; Andrew L Simon; Audrey E Wolfe; Samantha Smith; Laura Hou; Érick Moyneur; Juliane S Reynolds; Sengwee Toh; Angela Dobes; Lauren Parlett; Kevin Haynes; Jessica Burris; Jennifer E Dorand; Millie D Long; Michael D Kappelman

Publisher

Oxford University Press (OUP)

Published

2023

Language

EN

Field

Medicine (Health Sciences)