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Can I read Overexpression of the Human Major Vault Protein in Gangliogliomas on EtoBox?
Overexpression of the Human Major Vault Protein in Gangliogliomas by Eleonora Aronica; Jan A. Gorter; Erwin A. Van Vliet; Wim G. M. Spliet; Cees W. M. Van Veelen; Peter C. Van Rijen; Sieger Leenstra; Marja D. Ramkema; George L. Scheffer; Rik J. Scheper; Sanjay M. Sisodiya; Dirk Troost is a Medicine article available to read on EtoBox.
What is Overexpression of the Human Major Vault Protein in Gangliogliomas about?
**Summary:** __Purpose:__ Recent evidence has been obtained that the major vault protein (MVP) may play a role in multidrug resistance (MDR). We investigated the expression and cellular localization of MVP in gangliogliomas (GGs), which are increasingly recognized causes of chronic pharmacoresistant epilepsy. __Methods:__ Surgical tumor specimens (n = 30), as well as peritumoral and control brain tissues, were examined for the cellular distribution pattern of MVP with immunocytochemistry. Western blot analysis showed a consistent increase in MVP expression in GGs compared with that in control cortex. __Results:__ In normal brain, MVP expression was below detection in glial and neuronal cells, and only low immunoreactivity (IR) levels were detected in blood vessels. MVP expression was observed in the neuronal component of 30 of 30 GGs and in a population of tumor glial cells. In the majority of the tumors, strong MVP IR was found in lesional vessels. Perilesional regions did not show increased staining in vessels or in neuronal and glial cells compared with normal cortex. However, expression of MVP was detected in the hippocampus in cases with dual pathology. __Conclusions:__ The in
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- Author
- Eleonora Aronica; Jan A. Gorter; Erwin A. Van Vliet; Wim G. M. Spliet; Cees W. M. Van Veelen; Peter C. Van Rijen; Sieger Leenstra; Marja D. Ramkema; George L. Scheffer; Rik J. Scheper; Sanjay M. Sisodiya; Dirk Troost
- Publisher
- Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0013-9580)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)