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Can I read Cadherins Mediate Cocaine-induced Synaptic Plasticity and Behavioral Conditioning on EtoBox?
Cadherins Mediate Cocaine-induced Synaptic Plasticity and Behavioral Conditioning by Fergil Mills; Andrea K Globa; Shuai Liu; Catherine M Cowan; Mahsan Mobasser; Anthony G Phillips; Stephanie L Borgland; Shernaz X Bamji is a Neuroscience article available to read on EtoBox.
What is Cadherins Mediate Cocaine-induced Synaptic Plasticity and Behavioral Conditioning about?
Drugs of abuse alter synaptic connections in the reward circuitry of the brain, which leads to long-lasting behavioral changes that underlie addiction. Here we show that cadherin adhesion molecules play a critical role in mediating synaptic plasticity and behavioral changes driven by cocaine. We demonstrate that cadherin is essential for long-term potentiation in the ventral tegmental area and is recruited to the synaptic membranes of excitatory synapses onto dopaminergic neurons following cocaine-mediated behavioral conditioning. Furthermore, we show that stabilization of cadherin at the membrane of these synapses blocks cocaine-induced synaptic plasticity, leading to a reduction in conditioned place preference induced by cocaine. Our findings identify cadherins and associated molecules as targets of interest for understanding pathological plasticity associated with addiction.
Who reads Cadherins Mediate Cocaine-induced Synaptic Plasticity and Behavioral Conditioning?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Fergil Mills; Andrea K Globa; Shuai Liu; Catherine M Cowan; Mahsan Mobasser; Anthony G Phillips; Stephanie L Borgland; Shernaz X Bamji
- Publisher
- Springer Science and Business Media LLC
- Published
- 2017
- Language
- EN
- Field
- Neuroscience (Life Sciences)