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Diet-induced obesity increases melanoma progression: Involvement of Cav-1 and FASN by Vimal Pandey; Maleppillil Vavachan Vijayakumar; Amrendra Kumar Ajay; Parmanand Malvi; Manoj Kumar Bhat is a Medicine article available to read on EtoBox.
What is Diet-induced obesity increases melanoma progression: Involvement of Cav-1 and FASN about?
## Abstract Recent population‐based epidemiological studies strongly hint towards a link between obesity and its occurrence as well as progression of several cancers including melanoma. Although effects of obesity on breast, colon and liver cancers have been extensively investigated, the links between obesity and melanoma remain largely unexplored. Present study aimed to understand the effect of high fat diet‐induced weight gain on susceptibility of C57BL/6J mice to melanoma. For this, mice routinely were fed on high fat diet for 6 months (HFD mice). Subsequently, mouse melanoma cells were injected subcutaneously in control as well as HFD mice and followed for tumor initiation and progression. We provide strong evidence that diet‐induced obesity leads to increased melanoma progression in male C57BL/6J mice. We observed that increased melanoma progression is associated with enhanced Cav‐1 and FASN expression in tumors from HFD mice. Cav‐1 and FASN are co‐ordinately regulated and Cav‐1 interacts with FASN in melanoma cells. Enhanced levels of Cav‐1, FASN and pAkt control melanoma cell proliferation. Our study establishes a causative relationship between diet‐induced obesity and melan
Who reads Diet-induced obesity increases melanoma progression: Involvement of Cav-1 and FASN?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Vimal Pandey; Maleppillil Vavachan Vijayakumar; Amrendra Kumar Ajay; Parmanand Malvi; Manoj Kumar Bhat
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)