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Childhood Trauma Is Associated With Poorer Cognitive Performance in Older Adults by Andrew J. Petkus; Eric J. Lenze; Meryl A. Butters; Elizabeth W. Twamley; Julie Loebach Wetherell is a Medicine article available to read on EtoBox.

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## Objective: Childhood trauma is common and associated with both worse cognitive performance and disruption to the hypothalamic-pituitary-adrenal axis in younger adults. the extent to which these associations persist into older adulthood remains unknown. the aim of this study was to investigate self-reported childhood trauma in relation to cognitive performance, and the extent to which cortisol explained this association, in 2 independent samples of older adults. ## Methods: In this cross-sectional study, participants in the discovery sample (n = 76) consisted of older adults with a dsm-iv diagnosis of generalized anxiety disorder (n = 57) and age-equated psychiatrically healthy comparison subjects (n = 19) who were referred largely through primary care clinics between 2004-2006. the replication sample (n = 48) consisted of older adults with dsm-iv anxiety or depressive disorders recruited between 2012-2013. participants were administered the early trauma inventory self-report-short form and a neuropsychological assessment (primary outcome). ## Results: Across both samples, childhood trauma was significantly associated with worse performance on measures of processing speed, attent

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Author

Andrew J. Petkus; Eric J. Lenze; Meryl A. Butters; Elizabeth W. Twamley; Julie Loebach Wetherell

Publisher

Physicians Postgraduate Press, Inc

Published

2017

Language

EN

Field

Medicine (Health Sciences)