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Tumor Suppression by Apoptotic and Anti-angiogenic Effects of Mortalin-targeting Adeno-oncolytic Virus by Ji Young Yoo; Jihoon Ryu; Ran Gao; Tomoko Yaguchi; Sunil C. Kaul; Renu Wadhwa; Chae-Ok Yun is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Tumor Suppression by Apoptotic and Anti-angiogenic Effects of Mortalin-targeting Adeno-oncolytic Virus about?
## Abstract ## Background Adeno‐oncolytic (Adon) viruses offer an effective cancer therapeutic tool with several advantages, including wide host cell permeability, high transduction efficiency, safety, tumor selectivity, non‐invasiveness, high genetic modifiability and high level of expression of the integrated transgenes. Armed Adon viruses in which the therapeutic efficacy of virus is enhanced by their coupling with cytotoxic, anti‐angiogenic or anti‐vascular gene products have gained importance because they engage additional mechanisms for tumor cell killing. In the present study, we selected mortalin, a stress chaperone that is tightly involved in human carcinogenesis, constructed a mortalin‐targeting Adon (mot‐Adon) virus and examined its therapeutic potential both __in vitro__ and __in vivo.__ ## Methods Mortalin‐targeting plasmid and viral vectors that harbored mortalin‐specific small interfering RNA sequences were constructed. The therapeutic value of these vectors was investigated __in vitro__ and __in vivo__ by cell culture and nude mice tumor models. ## Results We demonstrate that the mot‐Adon virus has selective cytotoxicity for human cancer cells __in vitro.__ Retrovir
Who reads Tumor Suppression by Apoptotic and Anti-angiogenic Effects of Mortalin-targeting Adeno-oncolytic Virus?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Ji Young Yoo; Jihoon Ryu; Ran Gao; Tomoko Yaguchi; Sunil C. Kaul; Renu Wadhwa; Chae-Ok Yun
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1099-498X)
- Published
- 2010
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)