Can I read Meconium aspiration induces ARDS-like pulmonary response in lungs of ten-week-old pigs on EtoBox?

Meconium aspiration induces ARDS-like pulmonary response in lungs of ten-week-old pigs by Hanna Soukka; Markku Rautanen; Lauri Halkola; Pentti Kero; Pekka Kääpä is a Medicine article available to read on EtoBox.

What is Meconium aspiration induces ARDS-like pulmonary response in lungs of ten-week-old pigs about?

To investigate whether aspiration of meconium induces a hemodynamic and histologic pulmonary response similar to that frequently seen in experimental acute respiratory distress syndrome, twelve 10-week-old pigs with postnatally adapted lungs were studied. Six 10-week-old pigs received 3 ml/kg 20% human meconium via the endotracheal tube. Six control pigs of the same age were given sterile saline. Ventilator settings were adjusted to keep PaO 2 above 8 kPa and PaCO 2 below 5 kPa. The pulmonary hemodynamic response to aspiration consisted of two separate hypertensive components. An initial peak in pulmonary artery pressure (PAP) and pulmonary vascular resistance (PVR) was followed by a progressive increase in PAP and PVR in the meconium group, whereas in the saline group these parameters returned to baseline levels. The distribution of PVR, determined by pulmonary artery occlusion, was characterized by an increase in the postarterial resistance immediately after meconium aspiration and a progressive increase in both arterial and postarterial resistances during the later phase. On histological examination, marked neutrophil sequestration was seen in the meconium lungs. In addition, lu

Who reads Meconium aspiration induces ARDS-like pulmonary response in lungs of ten-week-old pigs?

Author

Hanna Soukka; Markku Rautanen; Lauri Halkola; Pentti Kero; Pekka Kääpä

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 8755-6863)

Published

1997

Language

EN

Field

Medicine (Health Sciences)