Opening book details…
Can I read A Comprehensive Genetic Profile of Phyllodes Tumours of the Breast Detects Important Mutations, Intra-tumoral Genetic Heterogeneity and New Genetic Changes on Recurrence on EtoBox?
A Comprehensive Genetic Profile of Phyllodes Tumours of the Breast Detects Important Mutations, Intra-tumoral Genetic Heterogeneity and New Genetic Changes on Recurrence by AM Jones; R Mitter; R Springall; T Graham; E Winter; C Gillett; AM Hanby; IPM Tomlinson; EJ Sawyer is a Medicine article available to read on EtoBox.
What is A Comprehensive Genetic Profile of Phyllodes Tumours of the Breast Detects Important Mutations, Intra-tumoral Genetic Heterogeneity and New Genetic Changes on Recurrence about?
## Abstract The aims of this study were to identify genetic changes associated with malignant progression of the fibroepithelial neoplasms, phyllodes tumours of the breast (PTs), and to ascertain whether genetic progression occurs when PTs recur locally. A further aim was to assess whether the genetic data support the classification of these tumours into three subtypes, benign, borderline and malignant. 126 PTs (37 benign, 41 borderline, 48 malignant) were analysed by either array‐CGH or the Illumina Goldengate assay. The large‐scale genetic changes associated with malignant/borderline phenotypes were + 1q, + 5p, + 7, + 8, − 6, − 9p, − 10p and − 13. Cluster analysis of the array‐CGH data supported the division of malignant and borderline PTs into two separate groups, one comprising almost all malignant lesions and the other, benign and borderline tumours. Interstitial deletions of 9p21 that involved the p16^INK4a^ locus were present in many malignant/borderline PTs, and some of these appeared to cause homozygous loss. Loss of expression of p16^INK4a^ was found frequently and this was associated with 9p deletion; we also identified one p16^INK4a^ mutation and evidence of methylation
Who reads A Comprehensive Genetic Profile of Phyllodes Tumours of the Breast Detects Important Mutations, Intra-tumoral Genetic Heterogeneity and New Genetic Changes on Recurrence?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- AM Jones; R Mitter; R Springall; T Graham; E Winter; C Gillett; AM Hanby; IPM Tomlinson; EJ Sawyer
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3417)
- Published
- 2008
- Language
- EN
- Field
- Medicine (Health Sciences)