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Evidence Accumulation for Value Computation in the Prefrontal Cortex During Decision Making by Lin, Zhongqiao; Nie, Chechang; Zhang, Yuanfeng; Chen, Yang; Yang, Tianming is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Evidence Accumulation for Value Computation in the Prefrontal Cortex During Decision Making about?

A key step of decision making is to determine the value associated with each option. The evaluation process often depends on the accumulation of evidence from multiple sources, which may arrive at different times. How evidence is accumulated for value computation in the brain during decision making has not been well studied. To address this problem, we trained rhesus monkeys to perform a decision-making task in which they had to make eye movement choices between two targets, whose reward probabilities had to be determined with the combined evidence from four sequentially presented visual stimuli. We studied the encoding of the reward probabilities associated with the stimuli and the eye movements in the orbitofrontal (OFC) and the dorsolateral prefrontal (DLPFC) cortices during the decision process. We found that the OFC neurons encoded the reward probability associated with individual pieces of evidence in the stimulus domain. Importantly, the representation of the reward probability in the OFC was transient, and the OFC did not encode the reward probability associated with the combined evidence from multiple stimuli. The computation of the combined reward probabilities was observ

Who reads Evidence Accumulation for Value Computation in the Prefrontal Cortex During Decision Making?

Author

Lin, Zhongqiao; Nie, Chechang; Zhang, Yuanfeng; Chen, Yang; Yang, Tianming

Publisher

National Academy of Sciences; Proceedings of the National Academy of Sciences; Oxford University Press (OUP); Publons; ScienceOpen (ISSN 0027-8424)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)