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Development and Validation of a Real-time Microelectrochemical Sensor for Clinical Monitoring of Tissue Oxygenation/perfusion by Gnahoré, Gama Theophile; Kelly, Jack L.; O'Riordan, Saidhbhe L.; Bolger, Fiachra B.; Doran, Michelle M.; Sands, Michelle; Lowry, John P. is a Chemistry article available to read on EtoBox.
What is Development and Validation of a Real-time Microelectrochemical Sensor for Clinical Monitoring of Tissue Oxygenation/perfusion about?
Oxygen is of critical importance to tissue viability and there is increasing demand for its reliable real-time clinical monitoring in order to prevent, diagnose, and treat several pathological disorders, including hypoxia, stroke and reperfusion injury. Herein we report the development and characterisation of a prototype clinical O2 sensor, and its validation in vivo, including proof-of-concept monitoring in patients undergoing surgery for carpal tunnel release. An integrated platinum-based microelectrochemical device was custom designed and controlled using a miniaturised telemetry-operated single channel clinical potentiostat. The in vitro performance of different sensor configurations is presented, with the best sensor design (S2) displaying appropriate linearity (R2 = 0.994) and sensitivity (0.569 ± 0.022 nA μM-1). Pre-clinical validation of S2 was performed in the hind limb muscle of anaesthetised rats; tourniquet application resulted in a significant rapid decrease in signal (90 ± 27%, [ΔO2] ca. 140 ± 18 μM), with a return to baseline within a period of ca. 3 min following tourniquet release. Similar trends were observed in the clinical study; an immediate decrease in signal
Who reads Development and Validation of a Real-time Microelectrochemical Sensor for Clinical Monitoring of Tissue Oxygenation/perfusion?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Gnahoré, Gama Theophile; Kelly, Jack L.; O'Riordan, Saidhbhe L.; Bolger, Fiachra B.; Doran, Michelle M.; Sands, Michelle; Lowry, John P.
- Publisher
- The Royal Society of Chemistry; Royal Society of Chemistry; Royal Society of Chemistry (RSC) (ISSN 1759-9660)
- Published
- 2020
- Language
- EN
- Field
- Chemistry (Physical Sciences)