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Can I read Glutathione and growth inhibition of Mycobacterium tuberculosis in healthy and HIV infected subjects on EtoBox?
Glutathione and growth inhibition of Mycobacterium tuberculosis in healthy and HIV infected subjects by Vishwanath Venketaraman; Tatanisha Rodgers; Rafael Linares; Nancy Reilly; Shobha Swaminathan; David Hom; Ariel C Millman; Robert Wallis; Nancy D Connell is a Medicine article available to read on EtoBox.
What is Glutathione and growth inhibition of Mycobacterium tuberculosis in healthy and HIV infected subjects about?
Intracellular levels of glutathione are depleted in patients with acquired immunodeficiency syndrome in whom the risk of tuberculosis, particularly disseminated disease is many times that of healthy individuals. In this study, we examined the role of glutathione in immunity against tuberculosis infection in samples derived from healthy and human immunodeficiency virus infected subjects. Our studies confirm that glutathione levels are reduced in peripheral blood mononuclear cells and in red blood cells isolated from human immunodeficiency virus-infected subjects (CD4>400/cumm). Furthermore, treatment of blood cultures from human immunodeficiency virus infected subjects with N-acetyl cysteine, a glutathione precursor, caused improved control of intracellular __M. tuberculosis__ infection. N-acetyl cysteine treatment decreased the levels of IL-1, TNF-α, and IL-6, and increased the levels of IFN-γ in blood cultures derived from human immunodeficiency virus-infected subjects, promoting the host immune responses to contain __M. tuberculosis__ infection successfully.
Who reads Glutathione and growth inhibition of Mycobacterium tuberculosis in healthy and HIV infected subjects?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Vishwanath Venketaraman; Tatanisha Rodgers; Rafael Linares; Nancy Reilly; Shobha Swaminathan; David Hom; Ariel C Millman; Robert Wallis; Nancy D Connell
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); [London]: BioMed Central, 2004-; Springer Science and Business Media LLC (ISSN 1742-6405)
- Published
- 2006
- Language
- EN
- Field
- Medicine (Health Sciences)