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Increasing the sensitivity of hyperpolarized [^15^N~2~]urea detection by serial transfer of polarization to spin‐coupled protons by Felix Kreis; Alan J. Wright; Vencel Somai; Rachel Katz‐Brull; Kevin M. Brindle is a Medicine article available to read on EtoBox.

What is Increasing the sensitivity of hyperpolarized [^15^N~2~]urea detection by serial transfer of polarization to spin‐coupled protons about?

## Purpose Hyperpolarized ^15^N‐labeled molecules have been proposed as imaging agents for investigating tissue perfusion and pH. However, the sensitivity of direct ^15^N detection is limited by the isotope's low gyromagnetic ratio. Sensitivity can be increased by transferring ^15^N hyperpolarization to spin‐coupled protons provided that there is not significant polarization loss during transfer. However, complete polarization transfer would limit the temporal window for imaging to the order of the proton T~1~ (2‐3 s). To exploit the long T~1~ offered by storing polarization in ^15^N and the higher sensitivity of ^1^H detection, we have developed a pulse sequence for partial polarization transfer. ## Methods A polarization transfer pulse sequence was modified to allow partial polarization transfer, as is required for dynamic measurements, and that can be implemented with inhomogeneous B~1~ fields, as is often the case in vivo. The sequence was demonstrated with dynamic spectroscopy and imaging measurements with [^15^N~2~]urea. ## Results When compared to direct ^15^N detection, the sequence increased the signal‐to‐noise ratio (SNR) by a factor of 1.72 ± 0.25, where both experiments

Who reads Increasing the sensitivity of hyperpolarized [^15^N~2~]urea detection by serial transfer of polarization to spin‐coupled protons?

Author

Felix Kreis; Alan J. Wright; Vencel Somai; Rachel Katz‐Brull; Kevin M. Brindle

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0740-3194)

Published

2020

Language

EN

Field

Medicine (Health Sciences)