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ONO-8815Ly, an EP2 agonist that markedly inhibits uterine contractions in women by M. Steinwall; M. Åkerlund; T. Bossmar; M. Nishii; M. Wright is a Medicine article available to read on EtoBox.

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**Objective** To determine the effect of ONO‐8815Ly on uterine contractions. **Design** A randomised, double‐blind, placebo‐controlled, dose‐ascending, cross‐over study. **Setting** Department of Obstetrics and Gynaecology, University Hospital of Lund, Sweden. **Population** Seventeen, healthy, parous and permanently sterilised women. **Methods** Intrauterine pressure was recorded on days 1–3 of bleeding of two menstruations. Subjects were intravenously treated with 4 or 8 μg/minute of ONO‐8815Ly or placebo for 130 minutes. Intravenous bolus injections of oxytocin, 50 pmol/kg body weight, were given 10 minutes before, during infusion after 60 and 120 minutes and 60 minutes after completion of infusion. The plasma concentrations of ONO‐8815Ly were measured in samples obtained immediately before each oxytocin injection. **Main outcome measure** Area under pressure recording curve (AUC) 10 minutes before and after each oxytocin injection. **Results** Twelve women, six in each dose group, completed both recordings. Of these, two women of each group were not included in efficacy analysis due to non‐responsiveness to oxytocin or missing baseline value. The AUC over 10 minutes before oxyt

Who reads ONO-8815Ly, an EP2 agonist that markedly inhibits uterine contractions in women?

Author

M. Steinwall; M. Åkerlund; T. Bossmar; M. Nishii; M. Wright

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1470-0328)

Published

2004

Language

EN

Field

Medicine (Health Sciences)