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Temporal profile of serum neurofilament light in multiple sclerosis: Implications for patient monitoring by Peter A Calabresi; Douglas L Arnold; Dipen Sangurdekar; Carol M Singh; Arman Altincatal; Carl de Moor; Bob Engle; Jaya Goyal; Aaron Deykin; Suzanne Szak; Bernd C Kieseier; Richard A Rudick; Tatiana Plavina is a Medicine article available to read on EtoBox.

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## Objective: To understand how longitudinal serum neurofilament light chain (sNfL) patterns can inform its use as a prognostic biomarker in multiple sclerosis (MS) and evaluate whether sNfL reflects MS disease activity and disease-modifying therapy usage. ## Methods: This was a post hoc analysis of longitudinal data and samples from the ADVANCE trial (NCT00906399) of patients with relapsing–remitting MS (RRMS). sNfL was measured every 3 months for 2 years, then every 6 months for 4 years. Regression models explored how sNfL data predicted 4-year values of brain volume, expanded disability status scale score, and T2 lesions. sNfL levels were assessed in those receiving placebo, peginterferon beta-1a, and those with disease activity. ## Results: Baseline sNfL was a predictor of 4-year brain atrophy and development of new T2 lesions. Clinical (__p__ = 0.02) and magnetic resonance imaging (MRI) (__p__ < 0.01) outcomes improved in those receiving peginterferon beta-1a whose sNfL decreased to <16 pg/mL after 12 months versus those whose sNfL remained ⩾16 pg/mL. Mean sNfL levels decreased in peginterferon beta-1a-treated patients and increased in placebo-treated patients (–9.5% vs. 6.8%;

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Author

Peter A Calabresi; Douglas L Arnold; Dipen Sangurdekar; Carol M Singh; Arman Altincatal; Carl de Moor; Bob Engle; Jaya Goyal; Aaron Deykin; Suzanne Szak; Bernd C Kieseier; Richard A Rudick; Tatiana Plavina

Publisher

SAGE Publications

Published

2020

Language

EN

Field

Medicine (Health Sciences)