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Efficacy of Stronger Neo‐Minophagen C compared between two doses administered three times a week on patients with chronic viral hepatitis by Kazuhiko Miyake; Toshiro Tango; Yasuhiko Ota; Keiji Mitamura; Makoto Yoshiba; Makoto Kako; Shigeki Hayashi; Yusei Ikeda; Norimasa Hayashida; Shogo Iwabuchi; Yuzuru Sato; Toshiaki Tomi; Naoya Funaki; Naoaki Hashimoto; Tomoyuki Umeda; Jun Miyazaki; Katsuaki Tanaka; Yasuo Endo; Hiroshi Suzuki is a Medicine article available to read on EtoBox.
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## Abstract **__Background:__** A daily injection of glycyrrhizin (Stronger Neo‐Minophagen C (SNMC) containing 40 mg glycyrrhizin in a 20 mL ampoule) lowers alanine aminotransferase (ALT) levels in patients with chronic viral hepatitis. **__Methods:__** The therapeutic effects of intermittent administration of SNMC three times a week for 12 weeks were evaluated and compared between two doses (40 and 100 mL) in a randomized clinical trial. **__Results:__** Overall, the therapeutic response was better in the 53 patients allocated 100 mL than the 59 who were allocated to have 40 mL SNMC (__P__ = 0.0243). At the completion of SNMC treatment, ALT levels decreased more extensively in the patients on 100 mL than those on 40 mL SNMC (−29 __vs__−50% in comparison with the baseline value, __P__ = 0.0002). Minor side‐effects occurred in both the patients on 100 mL (20%) and those on 40 mL (12%), but they did not require any therapies. **__Conclusions:__** Intermittent SNMC would be efficient in suppressing ALT levels in patients with chronic viral hepatitis in a dose‐dependent manner. Taken along with infrequent and very mild side‐effects, long‐term intermittent SNMC would benefit patients wi
Who reads Efficacy of Stronger Neo‐Minophagen C compared between two doses administered three times a week on patients with chronic viral hepatitis?
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- Author
- Kazuhiko Miyake; Toshiro Tango; Yasuhiko Ota; Keiji Mitamura; Makoto Yoshiba; Makoto Kako; Shigeki Hayashi; Yusei Ikeda; Norimasa Hayashida; Shogo Iwabuchi; Yuzuru Sato; Toshiaki Tomi; Naoya Funaki; Naoaki Hashimoto; Tomoyuki Umeda; Jun Miyazaki; Katsuaki Tanaka; Yasuo Endo; Hiroshi Suzuki
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0815-9319)
- Published
- 2002
- Language
- EN
- Field
- Medicine (Health Sciences)