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This document discusses the role of tumor suppressor genes (TSGs) in the tumor microenvironment (TME), highlighting how TSGs like TP53 and PTEN influence tumor growth through interactions with various cell types in the TME. The authors propose that TSGs may have both proactive and reactive roles in tumor development, depending on the sequence of events leading to malignancy. Additionally, they emphasize the importance of considering TSG expression in stromal cells for developing effective cancer treatments.

Author

julsama305

Language

EN