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Genetic polymorphisms of MRPS30-DT and NINJ2 may influence lung cancer risk by Shouchun Yan; Shouzhen Wu; Jia Wu; Qinlu Zhang; Yongjun He; Chao Jiang; Tianbo Jin is a Medicine article available to read on EtoBox.
What is Genetic polymorphisms of MRPS30-DT and NINJ2 may influence lung cancer risk about?
Lung cancer is one of the malignant tumors, and genetic background is a risk factor in lung cancer that cannot be neglected. In this study, we aimed to find out the effect of MRPS30-DT and NINJ2 variants on lung cancer risk. In this study, the seven selected singlenucleotide polymorphisms (SNPs) of MRPS30-DT and NINJ2 were genotyped in 509 lung cancer patients and 501 healthy controls based on the Agena MassARRAY platform. Odds ratios and 95% confidence intervals were calculated by logistic regression analysis to evaluate association between gene polymorphisms and lung cancer risk. False-positive report probability was also used to assess false-positive results. Furthermore, the interaction between SNPs was analyzed by multifactor dimensionality reduction to predict lung cancer risk. We identified the genotype TA of rs16901963 (T < A) in MRPS30-DT as a protective factor against lung cancer, while rs16901963-TT was significantly associated with an increased risk of lung cancer. We also revealed that the effect of MRPS30-DT and NINJ2 variants on the risk of lung cancer was dependent on age, gender, smoking, and drinking status. In conclusion, this study first proved that MRPS30-DT an
Who reads Genetic polymorphisms of MRPS30-DT and NINJ2 may influence lung cancer risk?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Shouchun Yan; Shouzhen Wu; Jia Wu; Qinlu Zhang; Yongjun He; Chao Jiang; Tianbo Jin
- Publisher
- Walter de Gruyter GmbH
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)