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Higher troponin T serum concentrations in hospital patients without diagnosed cardiac diseases compared to a population-based cohort by Romy Gessner; Christiane Gärtner; Maria Schmidt; Felix Eckelt; Kerstin Wirkner; Markus Löffler; Tobias Uhe; Berend Isermann; Ulrich Laufs; Thorsten Kaiser; Rolf Wachter is a Medicine article available to read on EtoBox.

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## Abstract ## Objectives Upper reference limits of high-sensitivity cardiac troponin T (hs-cTnT) are derived from healthy, population-based cohorts, and are frequently exceeded in hospitalized patients. In this study we aim to systematically examine the differences between in-hospital patients with no diagnosed cardiac diseases and a population-based cohort. ## Methods Retrospective analyses were performed in two independent cohorts. We included 5,652 participants of the prospective population-based LIFE cohort as well as 9,300 patients having been treated at our hospital between 2014 and 2021. In both cohorts, subjects with diagnosed or suspected cardiac diseases were excluded. We used Spearman’s rank correlation for correlation analyses of hs-cTnT serum concentrations and age. Sex- and age-adjusted 99th percentiles for hs-cTnT in subjects with preserved renal function were obtained in both cohorts. ## Results In both cohorts, hs-cTnT serum concentrations positively correlated with age. Male sex was associated with higher hs-cTnT serum concentrations. Persons treated in hospital showed significantly higher hs-cTnT concentrations in females and males aged above 50. While in the po

Who reads Higher troponin T serum concentrations in hospital patients without diagnosed cardiac diseases compared to a population-based cohort?

Author

Romy Gessner; Christiane Gärtner; Maria Schmidt; Felix Eckelt; Kerstin Wirkner; Markus Löffler; Tobias Uhe; Berend Isermann; Ulrich Laufs; Thorsten Kaiser; Rolf Wachter

Publisher

Walter de Gruyter GmbH

Published

2023

Language

EN

Field

Medicine (Health Sciences)